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Distinct control of PERIOD2 degradation and circadian rhythms by the oncoprotein and ubiquitin ligase MDM2

Jones 3 , Bolin Niu 4 , George Therapondos 5 , Mae Thamer 6 , Onkar Kshirsagar 6 , Yi Zhang 6 , Paulo Pinheiro 7 , Ronnie Fass 8 , Mandana Khalili 9 and Amit G

The observed frequency mismatch therefore does not contradict the role of peripheral damage in initiating central hyperactivity

For example, in a myocardial reperfusion injury model, curcumin inhibits ferroptosis, autophagy, and apoptosis by upregulating HES1, effectively reducing tissue damage (172)

This work shows that in CRC the emergence of DTP cells may be associated with transdifferentiation, as has been observed in other tumour types